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KMID : 0376219820190030349
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Chonnam Medical Journal
1982 Volume.19 No. 3 p.349 ~ p.357
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The Enzyme histochemical Studies on the Salivary Gland in Acute and Chronic Malathion-poisoned Rats
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Abstract
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The purpose of this study is to determine the effect of malathion on the enzyme activities of the salivary glands in rats.
Two groups of animals, an acute-poisoned and a chronic-poisoned, were administered with malathion at the doses of 100mg/1008 body weight for 3 days and 10 mg/100 9 B. W. for 30 days respectively. The animals were then sacrificed on the following day after the last treatment, and then histochemical enzyme histocnemical studies were carried out in the parotid glands.
The results were as follows.
1. In both the acute and chronic poisonings only a slight decrease of mucosubstance was noted in gland.
2., Acute poisoning caused a moderate increase of acid and alkaline phosphatases in the acini and of acid phosphatase in the duct and these increase of enzyme activities with chronic poisoning appear to be slighter than those of the acute poisoning.
3. Acute poisoning caused the slight decrease of nonspecific esterease and succinic dehydrogenase both in the acini and in the duct, however, the enzyme activity showed no appreciable change after chronic poisoning.
4. There was no change in APTase activities of either the acini or the duct, in both groups.
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